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Treatment related adverse events seen in clinical trials with Latanoprost / Timolol 50 micrograms / ml + 5 mg / ml Eye Drops, Solution are listed below. A milliliter (also written "millilitre", SI symbol ml) is a non-SI metric system unit of volume which is commonly used as liquid unit. It is equal to 1/1000 liter, or one cubic centimeter, therefore, 1ml = 1/1000 L =1 cm3. Definition of Teaspoon
Before treatment is instituted patients should be informed of the possibility of a change in eye colour. Unilateral treatment can result in permanent heterochromia.For latanoprost, the majority of adverse events relate to the ocular system. In data from the extension phase of Latanoprost / Timolol pivotal trials, 16 - 20% of patients developed increased iris pigmentation, which may be permanent. In an open 5 year latanoprost safety study, 33% of patients developed iris pigmentation (see section 4.4). Other ocular adverse events are generally transient and occur on dose administration. For timolol, the most serious adverse events are systemic in nature, including bradycardia, arrhythmia, congestive heart failure, bronchospam and allergic reactions.
Increased risk of ventricular arrythmias with quinuprisin/dalfoprisin. Concomitant use should be avoided.Summary of Product Characteristics: Brodilaten 2.5mg/2.5ml nebuliser solution. Noridem Enterprises Limited. Revised July 2019. chest pain, abnormal heart rhythm, increased heart beat, worsening of asthma, diarrhea, nose bleeds, Systemic allergic reactions including angioedema, urticaria, localized and generalized rash, pruritus, anaphylactic reaction. The half-life of timolol in plasma is about 6 hours. Timolol is extensively metabolised in the liver.